Unforgettable Books
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Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics (2014)
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
$199.99
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Systems of Innovation: Technologies, Institutions and Organizations: Technologies, Institutions and Organizations
The systems of innovation approach is considered by many to be a useful analytical approach for better understanding innovation processes as well as the production and distribution of knowledge in the economy. It is an appropriate framework for the empirical study of innovations in their contexts and is relevant for policy makers. This text is the result of the work within an international inter-disciplinary network or working seminar with the task of building a more solid and sophisticated conceptual and theoretical foundation for the continued study of innovations in a systemic context. The book has three parts. The first presents an overview and tries to work out some conceptual problems. In the second, the systems of innovation approach is related to innovation theory. Part three is devoted to increasing understanding of the functioning and dynamics of systems of innovation. There is also an introduction where the genesis and anatomy of different systems of innovation approaches are discussed and where the systems of innovation approach is characterized in nine dimensions.
$230.00
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Cities Enterprise and Society
This collection of essays provides a review and restatement of concepts and analytical insights about the relations between the dynamics of the production system and urban society. A number of questions underline the arrangement of the book, and constitute the central debates in the individual chapters. These questions include: how have large cities and city systems developed in the context of economic globalization and the restructuring processes of the international economy?; what are the restructuring strategies of firms within the urban economy?; how have social and political harmonization and polarization in urban society been affected by entrepreneurial strategies?; and what has been the response of other urban participants, and in particular local authorities to economic restructuring?
$260.00
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Noise Control Management
Noise Control Management presents a system-wide management approach to the many noise-related problems that plague industrial settings. Students learn how to define noise problems and determine the feasibility of mitigating them. The text shows how to identify noise sources and set up priorities for dealing with the problems these sources create. Coverage includes a full range of noise control devices, from quiet equipment to barriers, enclosures, silencers, and other devices.
$251.95
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The Irish Establishment 1879-1914
The Irish Establishment examines who the most powerful men and women were in Ireland between the Land War and the beginning of the Great War, and considers how the composition of elite society changed during this period. Although enormous shifts in economic and political power were taking place at the middle levels of Irish society, Fergus Campbell demonstrates that the Irish establishment remained remarkably static and unchanged. The Irish landlord class and the Irish Protestant middle class (especially businessmen and professionals) retained critical positions of power, and the rising Catholic middle class was largely--although not entirely--excluded from this establishment elite. In particular, Campbell focuses on landlords, businessmen, religious leaders, politicians, police officers, and senior civil servants, and examines their collective biographies to explore the changing nature of each of these elite groups. The book provides an alternative analysis to that advanced in the existing literature on elite groups in Ireland. Many historians argue that the members of the rising Catholic middle class were becoming successfully integrated into the Irish establishment by the beginning of the twentieth century, and that the Irish revolution (1916-23) represented a perverse turn of events that undermined an otherwise happy and democratic polity. Campbell suggests, on the other hand, that the revolution was a direct result of structural inequality and ethnic discrimination that converted well-educated young Catholics from ambitious students into frustrated revolutionaries. Finally, Campbell suggests that it was the strange intermediate nature of Ireland's relationship with Britain under the Act of Union (1801-1922)--neither straightforward colony nor fully integrated part of the United Kingdom--that created the tensions that caused the Union to unravel long before Patrick Pearse pulled on his boots and marched down Sackville Street on Easter Monday in 1916.
$200.00
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Iutam Symposium on Advances in Micro- And Nanofluidics: Proceedings of the Iutam Symposium on Advances in Micro- And Nanofluidics, Dresden, Germany, S
Micro and nano-fluidics concerns fluid dynamics occurring in devices or flow configurations with minimum design length measured in micrometers or smaller. The behavior of fluids at these scales is quite different from that at the macroscopic level due to the presence of surface tension effects, wetting phenomena, Brownian diffusion and hydrodynamic interactions with immersed particles and microstructures. These effects cannot be generally represented in a classical homogeneous continuum framework. However, this triggers the development of new tools to investigate and simulate problems at the meso-scopic level. This book contains a collection of works presented at the IUTAM Symposium on Advances on Micro and Nano-fluidics held in Dresden in 2007. It covers several subjects of wide interest for micro and nano-fluidics applications focusing on both, analytical and numerical approaches. Topics covered in particular include multi-scale particle methods for numerical simulations, liquid-wall interactions and modeling approaches, modeling of immersed nano-scale structures, organized flow behavior at micro and nano-scales, and methods for control of micro- and nano-scale flows.
$109.99
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La concorrenza sleale dell'ombelico
Perché le ragazze d'inverno vanno in giro con sciarpa e guanti e la pancia scoperta? Come si fa a tradire la Ferilli? Cosa si può trovare in un'altra donna che la Ferilli non abbia già in abbondanza? Perché una volta passavamo le domeniche pomeriggio ascoltando le partite alla radio e adesso spingiamo il carrello della nostra ragazza all'Ikea? Le domande a cui i trentenni in crisi di oggi cercano di dare risposta in attesa di diventare quarantenni e, finalmente, capire tutto.
$23.50
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$39.50
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The Economics of Property-Casualty Insurance
The Economics of Property-Casualty Insurance presents new research and findings on key aspects of the economics of the property-casualty insurance industry. The volume explores the industrial organization, regulation, financing, and taxation of this business. The first paper, on external financing and insurance cycles, contains a wealth of information on trends and patterns in the industry's financial structure. The last essay, which compares performance of stock and mutual insurance companies, takes a fresh look at the way a company's organizational structure affects its responses to different economic situations. Two papers focus on rate regulation in the auto insurance industry, and provide broad overviews of the structure and economics of the insurance industry as a whole. Also addressed are the system of regulating insurance companies in the United States, who insures the insurers, and the effects of tax law changes in the 1980s on the prices of insurance policies.
$64.00
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Transport Regulation Matters
Transport has become a major concern on both social and economic grounds in the late-twentieth century. This concern arises from a perception of the industry's failure to respond to the rapid growth in demand and to the threat of congestion and environmental pollution. A solution has been sought in economic policies dominated by ideas of liberalization and deregulation.
$155.00 $150.00
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Cytokines and Growth Factors in Blood Transfusion: Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, Organi
Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient. Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information. Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume: Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions. Function, production and diagnosis &endash; laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors. Application in clinical medicine &endash; clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis. Future potential use in transfusion medicine &endash; erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.
$179.00
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The Materiality of Individuality: Archaeological Studies of Individual Lives (2009): Archaeological Studies of Individual Lives
Generally individuals in history are known for a particular reason - they somehow influenced history. Very little is known about the ordinary person who lived in the past. But historical archaeologists - through their interpretation of the material culture and historic record - can study the past on an individual level. This brings archaeological interpretation from a micro to a macro level - as opposed to the traditional level of society to community to individual interpretation. The cases presented in this volume engage material culture that is owned or used by a single person and is thus associated with an individual at some point in its uselife. The volume takes bodkins, shoes, beads, cloth, religious items, grave goods, as well as subassemblages from well-defined contexts from New England, the Chesapeake, New Orleans, Hawaii, Spanish colonial America, and London in the pursuit of the individual and the textured interpretation this analytical scale provides. This volume promises to present innovative approaches to a host of archaeological materials, drawing widely on the range of archaeological research for the historical period today. Capitalizing on several topics and research threads with great currency, such as the examination of material culture and interest in various and intersecting lines of identity construction, as well as presenting an international and multiregional approach to these topics, this volume will be of interest to archaeologists, anthropologists, material culture scholars, and social historians interested in a wide variety of time periods and subfields.
$109.99
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