Books
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Thermodynamics of Solutions: From Gases to Pharmaceutics to Proteins (2009)
This book consists of a number of papers regarding the thermodynamics and structure of multicomponent systems that we have published during the last decade. Even though they involve different topics and different systems, they have something in common which can be considered as the "signature" of the present book. First, these papers are concerned with "difficult" or very nonideal systems, i. e. systems with very strong interactions (e. g., hyd- gen bonding) between components or systems with large differences in the partial molar v- umes of the components (e. g., the aqueous solutions of proteins), or systems that are far from "normal" conditions (e. g., critical or near-critical mixtures). Second, the conventional th- modynamic methods are not sufficient for the accurate treatment of these mixtures. Last but not least, these systems are of interest for the pharmaceutical, biomedical, and related ind- tries. In order to meet the thermodynamic challenges involved in these complex mixtures, we employed a variety of traditional methods but also new methods, such as the fluctuation t- ory of Kirkwood and Buff and ab initio quantum mechanical techniques. The Kirkwood-Buff (KB) theory is a rigorous formalism which is free of any of the - proximations usually used in the thermodynamic treatment of multicomponent systems. This theory appears to be very fruitful when applied to the above mentioned "difficult" systems.
$174.99 $169.99
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Dynamic and Transient Infinite Elements: Theory and Geophysical, Geotechnical and Geoenvironmental Applications (2009)
Effective and ef cient modelling of in nite media is important for the production of accurate and useful solutions for many scienti c and engineering problems invo- ing in nite domains (Bettess 1977, 1980; Chow and Smith 1981; Medina and Taylor 1983; Zhang and Zhao 1987; Zhao et al. 1989; Zhao and Valliappan 1993a, b, c, d; Astley 1996, 1998; Yang et al. 1996; Yang and Huang 2001; Yun et al. 2000, 2007; Wang et al. 2006). Some typical examples involving in nite domains are as follows: (1) earthquake wave propagation within the upper crust of the Earth in the elds of geophysics and seismology; (2) dynamic structure-foundation interaction in the elds of geotechnical, civil and dam engineering; and (3) transient pore- uid ow, heat transfer and mass transport within the interior of the Earth in the elds of g- science and geoenvironmental engineering. Although the solid Earth is viewed as a bounded domain at the terrestrial scale, it can be treated as an unbounded domain at the human scale. For instance, in the case of predicting possible property damages caused by an earthquake, only a limited region around the epicentre is of interest because the earthquake wave energy is signi cantly reduced as the distance from the epicentre is increased.
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Superior-Order Curvature-Correction Techniques for Voltage References (2009)
Voltage references represent important VLSI structures, having multiple appli- tions in analog and mixed-signal circuits: measurement equipment, voltage re- lators, temperature sensors, data acquisition systems, memories, or AD and DA converters. Operating as a subcircuit in a complex system, an important requi- ment for this class of circuits is represented by the possibility of implementation in the existing technology, using the available active and passive devices. The most important performances of a voltage reference circuit are represented by temperature behavior, power supply rejection ratio, transient response and, for the latest designs, by low-power low-voltage operation. Depending on the load - quirements, the output of the circuit can be regulated or unregulated. In order to reduce the sensitivity of the reference voltage with respect to the supply voltage variations, modi?ed cascode structures can be implemented, a trade-off between line regulation and low-voltage operation being necessary in this case. A large bandwidth of the voltage reference improves the transient behavior of the circuit, implying also a good noise rejection. Referringtothe possibilities ofimplementinga voltagereferencecircuit, two d- ferent approaches could be identi?ed: voltage-mode and current-mode topologies, being also possible to design a mixed-mode voltage reference.
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Reactive Oxygen Species in Plant Signaling (2009)
Oxygen (O ) appeared in significant amounts in the Earth's atmosphere over 2. 2 2 billion years ago, largely due to the evolution of photosynthesis by cyanobacteria (Halliwell 2006). The O molecule is a free radical, as it has two impaired electrons 2 that have the same spin quantum number. This spin restriction makes O prefer to 2 accept its electrons one at a time, leading to the generation of the so-called reactive oxygen species (ROS). The chemical nature of these species dictates that they can create damage in cells. This has contributed to the creation of the "oxidative stress" concept; in this view, ROS are unavoidable toxic products of O metabolism and 2 aerobic organisms have evolved antioxidant defences to protect against this tox- ity (Halliwell 1981; Fridovich 1998). Indeed, even in present-day plants, which are full of antioxidants, much of the protein synthetic activity of chloroplasts is used to replace oxidatively damaged D1 and other proteins (Halliwell 2006). Yet, the use of the "oxidative stress" term implies that ROS exert their effects through indiscriminate widespread inactivation of cellular functions. In this context, ROS must not be able to react with lipids, proteins or nucleic acids in order to avoid any damage to vital cellular components. However, genetic evidence has suggested that, in planta, purely physicoche- cal damage may be more limited than previously thought (Foyer and Noctor 2005).
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Emergence, Analysis and Evolution of Structures: Concepts and Strategies Across Disciplines (2010)
In May 2002 a number of about 20 scientists from various disciplines were invited by the Berlin-Brandenburg Academy of Sciences and Humanities to participate in an interdisciplinary workshop on structures and structure generating processes. The site was the beautiful little castle of Blankensee, south of Berlin. The disciplines represented ranged from mathematics and information theory, over various ?elds of engineering, biochemistry and biology, to the economic and social sciences. All participants presented talks explaining the nature of structures considered in their ?elds and the associated procedures of analysis. It soon became evident that the study of structures is indeed a common c- cern of virtually all disciplines. The motivation as well as the methods of analysis, however, differ considerably. In engineering, the generation of artifacts, such as infrastructures or technological processes, are of primary interest. Frequently, the analysis aims there at de?ning a simpli?ed mathematical model for the optimization of the structures and the structure generating processes. Mathematical or heuristic methods are applied, the latter preferably of the type of biology based evolutionary algorithms. On the other hand, setting up complex technical structures is not pos- ble by such simpli?ed model calculations but requires a different and less model but rather knowledge-based type of approach, using empirical rules rather than formal equations. In biochemistry, interest is frequently focussed on the structures of molecules, such as proteins or ribonucleic acids. Again, optimal structures can usually be de?ned.
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Male Reproductive Cancers: Epidemiology, Pathology and Genetics (2010)
Knowledge about cancer genetics is rapidly expanding, and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment. Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk. Today, the NCI is putting more and more money into research into the genetics of cancer. The very first of the NCI's stated research priorities is a project called The Cancer Genome Atlas. The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The NCI and the NHGRI (National Human Genome Research Institute, where the series editor is employed) have each committed $50 million over three years to the TCGA Pilot Project. This book proposes cover the latest findings in the genetics of male reproductive cancers; specifically cancers of the prostate and testes. The volume will cover the epidemiology of these cancers; model systems, pathology, molecular genetics, and inherited susceptibility.
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Recent Developments in Management of Plant Diseases (2009)
Plant disease management remains an important component of plant pathology and is more complex today than ever before including new innovation in diagnostic kits, the discovery of new modes of action of chemicals with low environmental impact, biological control agents with reliable and persistent activity, as well as the development of new plant varieties with durable disease resistance. This book is a collection of invited lectures given at the 9th International Congress of Plant Pathology (ICPP 2008), held in Torino, August 24-29, 2008 and is part of a series of volumes on Plant Pathology in the 21st Century. It focuses on new developments of disease management and provides an updated overview of the state of the art given by world experts in the different fields of disease management. The different chapters deal with basic aspects of disease management, mechanisms of action of biological control agents, innovation in fungicide application, exploitation of natural compounds and resistance strategies. Moreover, the management of soil-borne diseases and disease management in organic farming are covered.
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Advanced Nanoscale ULSI Interconnects: Fundamentals and Applications (2009)
In Advanced ULSI interconnects - fundamentals and applications we bring a comprehensive description of copper-based interconnect technology for ultra-lar- scale integration (ULSI) technology for integrated circuit (IC) application. In- grated circuit technology is the base for all modern electronics systems. You can ?nd electronics systems today everywhere: from toys and home appliances to a- planes and space shuttles. Electronics systems form the hardware that together with software are the bases of the modern information society. The rapid growth and vast exploitation of modern electronics system create a strong demand for new and improved electronic circuits as demonstrated by the amazing progress in the ?eld of ULSI technology. This progress is well described by the famous "Moore's law" which states, in its most general form, that all the metrics that describe integrated circuit performance (e. g., speed, number of devices, chip area) improve expon- tially as a function of time. For example, the number of components per chip d- bles every 18 months and the critical dimension on a chip has shrunk by 50% every 2 years on average in the last 30 years. This rapid growth in integrated circuits te- nology results in highly complex integrated circuits with an increasing number of interconnects on chips and between the chip and its package. The complexity of the interconnect network on chips involves an increasing number of metal lines per interconnect level, more interconnect levels, and at the same time a reduction in the interconnect line critical dimensions.
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Digitale Signalverarbeitung 2: Entwurf Diskreter Systeme (2010)
Der zweite Teil der "Digitalen Signalverarbeitung" von Prof. Hans W. Schüssler gibt eine fundierte und ausführliche Einführung in den Entwurf digitaler Systeme und legt einen wesentlichen Schwerpunkt auf die Analyse und das Design digitaler Filter. Diese Erstausgabe basiert auf dem Manuskript von H. W. Schüssler, das von G. Dehner, R. Rabenstein und P. Steffen bearbeitet wurde. Wie der Band 1 ist auch dieser zweite Band von einer umfangreichen Matlab-Bibliothek begleitet, die im Internet zur Verfügung gestellt wird.
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Integrated Assessment of China's Ecological Restoration Programs (2009)
China has been undertaking unprecedented ecological restoration efforts to deal with its problems of soil erosion, flooding, dust storms, and habitat loss. While there have been studies of these efforts, questions remain concerning whether they have been effectively implemented, what their induced socioeconomic and ecological impacts are, and how their performance can be improved. Tackling these important questions in an integrated manner, "An Integrated Assessment of China's Ecological Restoration Programs" is extraordinary for its broad coverage and methodological rigor. It provides a substantial improvement over the conventional approach of simply reporting projects undertaken and accepting uncritically the government assessment, and thus fills an important knowledge gap of the restoration efforts being implemented upon a variety of ecosystems in China.
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Environmental and Workplace Safety: A Guide for University, Hospital, and School Managers
Environmental and Workplace Safety A Guide for University, Hospital, and School Managers James T. O'Reilly Philip Hagan Peter de la Cruz Environmental and Workplace Safety is the first book to provide health, safety, and environmental managers at health care and educational organizations with the comprehensive and up-to-date regulatory and compliance information needed to avoid costly penalties and litigation. It also offers sound guidance on how managers, with the aid of consultants and legal counsel, can develop cost-effective safety and environmental programs to comply with OSHA, DOT, and EPA standards. Environmental and Workplace Safety defines the regulatory problems facing nonprofit organizations and the types of liability their managers and employees are exposed to--since contrary to popular belief, nonprofits are not exempt from compliance and enforcement. Bringing together widely scattered information, this essential resource addresses a wide range of workplace-risk issues, and explains the institution's liability if regulations are violated Coverage includes: * General building safety concerns such as indoor air, lead, asbestos, and electrical safety * Groundwater issues such as underground storage tanks and industrial effluents * Biologically hazardous waste and other laboratory hazards * Air pollution permits required under Title V * OSHA-mandated safety training for a facility's workers and students In addition, this convenient handbook alerts managers to newer potential sources of liability, such as the accidental release of viruses and bacteria in biotechnology experiments, injuries caused by an institution's waste, rapes and assaults in unsafe dormitories and parking lots, and community opposition to hospital and college zoning requests. In each case, the book gives managers cost-effective compliance solutions to these problems to prevent the expensive litigation and negative publicity they can engender. Finally, Environmental and Workplace Safety fosters a new understanding of the importance of safety and environmental professionals within their organizations, enhancing their status and increasing their ability to obtain the resources they need to do their jobs more effectively.
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Leonardo's Choice: Genetic Technologies and Animals (2009)
Leonardo's Choice: Genetic Technologies and Animals is an edited collection of twelve essays and one dialogue focusing on the profound affect the use of animals in biotechnology is having on both humans and other species. Communicating crucial understandings of the integrated nature of the human and non-human world, these essays, unlike the majority of discussions of biotechnology, take seriously the impact of these technologies on animals themselves. This collection's central questions revolve around the disassociation Western ideas of creative freedom have from the impacts those ideas and practices have on the non-human world.This transdisciplinary collection includes perspectives from the disciplines of philosophy, cultural theory, art and literary theory, history and theory of science, environmental studies, law, landscape architecture, history, and geography. Included authors span three continents and four countries.Included essays contribute significantly to a growing scholarship surrounding "the question of the animal" emanating from philosophical, cultural and activist discourses. Its authors are at the forefront of the growing number of theorists and practitioners across the disciplines concerned with the impact of new technologies on the more-than-human world.
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